In the LSD-sure crystal structure, the side chain with the lid residue L209EL2 sorts considerable hydrophobic contacts with both of those LSD and bordering residues in TMs III, IV, and V (Determine 4C). If the lid moved aside to reveal the binding pocket in simulation, several of those contacts broke. https://lsdvial87405.full-design.com/lsd-vial-an-overview-77462759