Pentobarbital will decrease the level or effect of hydrocortisone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. pentobarbital will decrease the level or effect of quinine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. When barbiturates like Nembutal are abused, they are not usually the primary drug of abuse. Like https://sound-social.com/story10513786/the-ultimate-guide-to-pentobarbital-de-sodium